German Chip Register – Deutsches CHIP Register


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What is CHIP?

Clonal hematopoiesis of undetermined potential (CHIP) is a disease in which genetic mutations are present in white blood cells that can increase the risk of developing blood cancers such as leukemia and lymphoma.

It often occurs in older adults and usually causes no symptoms.

While CHIP is not itself a form of cancer, it can increase the risk of developing cancer in the future. Not all people with CHIP develop cancer, and the risk varies depending on the specific mutations and individual factors.

Further, it has been recognized that CHIP is a risk factor for cardiovascular disease in its own right and has a greater effect than the classic risk factors of hypertension, hypercholesterolemia, diabetes and smoking. It doubles the risk of heart attack, stroke and premature death.

The risk for heart attacks in people under age 65 is increased fourfold. If you have been diagnosed with CHIP, close monitoring of your blood, optimized adjustment of your cardiovascular risk factors, and regular follow-up visits are recommended.

It is important to maintain a healthy lifestyle and follow recommendations for screening and prevention. Overall, while the presence of CHIP can be worrisome, with proper monitoring and care, most people with this condition can live full lives.


Dr. med. Dr. med. univ. Moritz von ScheidtFacharzt für Innere Medizin und Kardiologie
Dr. med. Judith HeckerOberärztin für Innere Medizin und Hämatologie und Onkologie