CHIP mutations significantly increase the risk of cardiovascular heart disease such as myocardial infarction and stroke, as well as premature death. The level of risk depends on the specific mutation and the mutation load (proportion of mutated leukocytes).

To date, CHIP-specific therapies have only been used in trials. These are usually aimed at reducing inflammation and have not yet been approved for all patients. In general, follow a healthy lifestyle, control your blood pressure and cholesterol levels, quit smoking, exercise regularly, reduce stress, maintain a heart-healthy diet, take your medications, and see your healthcare provider for regular checkups.

Yes, a heart-healthy lifestyle is critical to lowering your risk of heart attack – especially as a CHIP mutation carrier. Make sure you eat a balanced diet low in saturated fat and trans fat, exercise regularly, reduce stress and maintain a healthy weight. These lifestyle changes will help improve your overall cardiovascular health.

Cardiovascular events are most commonly observed in association with CHIP. However, CHIP mutations also slightly increase your risk of developing blood cancers, such as acute myeloid leukemia (AML). Regular checkups and close communication with your medical team will help identify and treat potential complications.

Depending on your underlying mutation and mutation burden, an individual risk will result. All patients with CHIP should be monitored at a specialized CHIP clinic at least once a year. Patients at particularly high risk are seen at shorter intervals to monitor your cardiovascular health and assess for possible progression. This includes regular blood tests, consistent adjustment of risk factors, and further cardiovascular evaluation if necessary.

Currently, infrastructure for CHIP patients is increasingly being established throughout Germany. In Munich, a CHIP outpatient clinic already exists at the Klinikum Rechts der Isar, which provides both hematological and cardiovascular advice to your patients.