The German CHIP Registry contributes to optimize the care of affected individuals in the future. It provides individuals with clonal hematopoiesis of undetermined potential (CHIP) with easy-to-understand information, prospective follow-up and potential treatment options. The German CHIP Registry is designed to help reduce the individual risk of affected individuals in the future to avoid serious events such as heart attack, stroke and blood cancer.

The registry is offered free of charge by the German Heart Centre Munich and the Hematology and Oncology Department of the Klinikum rechts der Isar of the Technical University of Munich. The registry is supported by the professional societies of cardiology and hematology.

Recent studies have shown that CHIP is associated with a strong inflammatory component. Inflammation has been shown to be a key factor increasing the risk of cardiovascular events in individuals with CHIP mutations.

This may offer the possibility of anti-inflammatory therapy as a potential treatment for CHIP carriers in the coming years. Three overarching goals are being pursued with the establishment of the German CHIP Registry.

• We aim to gain further insight into the incidence, risk factors, and natural progression of CHIP. This information can be used for guideline development, treatment and monitoring of individuals with CHIP.
• The establishment of the German CHIP Registry facilitates the identification of individuals at high risk for progression of cardiovascular and hematologic disease. The registry allows for targeted monitoring and potential early intervention in the future.
• The establishment of the German CHIP Registry helps to identify individuals who are eligible to participate in clinical trials and to use promising therapies of CHIP and who actively want to do so.